Ltn1 | listerin E3 ubiquitin protein ligase 1

GeneMGI:1926163Synonyms: Rnf160, Listerin, +2 more

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

63Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased circulating alkaline phosphatase level	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.23x10^-10
no spontaneous movement	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.59x10^-5
increased lung elastance	3 supporting datasets	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.47x10^-6
increased freezing behavior	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.59x10^-5
increased red blood cell distribution width	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.8x10^-6
increased lung tissue damping	2 supporting datasets	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.29x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased airway resistance	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.65x10^-5
thrombocytopenia	1 supporting dataset	Ltn1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.53x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ltn1.

Associated images

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Histopathology

There is no histopathology data found for Ltn1.

IMPC related publications

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External links

No external links available for Ltn1.

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*Ltn1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ltn1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ltn1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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