Usp54 | ubiquitin specific peptidase 54

GeneMGI:1926037Synonyms: 4930429G18Rik, C030002J06Rik

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased circulating aspartate transaminase level	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.72x10^-7
enlarged heart	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.25x10^-19
decreased hemoglobin content	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.39x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.54x10^-7
decreased circulating amylase level	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.77x10^-5
increased neutrophil cell number	2 supporting datasets	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.78x10^-21
decreased exploration in new environment	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.58x10^-5
decreased circulating total protein level	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.14x10^-5
increased red blood cell distribution width	1 supporting dataset	Usp54^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.51x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Usp54.

Associated images

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Histopathology

There is no histopathology data found for Usp54.

IMPC related publications

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External links

No external links available for Usp54.

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*Usp54^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Usp54^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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