Arhgap10 | Rho GTPase activating protein 10

GeneMGI:1925764Synonyms: PSGAP-s, PSGAP-m, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Skeleton

11 No significant impact

6 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased mean platelet volume1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adult1.03x10-18 
abnormal bone structure1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adult7.65x10-7 
abnormal sternum morphology1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adultN/A * 
enlarged lymph nodes1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adultN/A * 
decreased body length1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adult4.85x10-6 
abnormal skin morphology1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adultN/A * 
abnormal ovary morphology1 supporting datasetArhgap10em1(IMPC)TcphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Arhgap10em1(IMPC)TcpExon Deletionmouse
Arhgap10tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Arhgap10tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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