Spink12 | serine peptidase inhibitor, Kazal type 12

GeneMGI:1925492Synonyms: 9230117E20Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Vision/eye Hematopoietic system Behavior/neurological

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal startle reflex	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Late adult	9.56x10^-6
decreased blood urea nitrogen level	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Early adult	1.32x10^-7
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Early adult	1.25x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Early adult	4.83x10^-7
abnormal coat/hair pigmentation	3 supporting datasets	Spink12^em1(IMPC)J	homozygote	Late adult	1.02x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Late adult	1.2x10^-9
increased grip strength	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Early adult	5.04x10^-5
abnormal retina morphology	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Late adult	6.02x10^-5
increased circulating bilirubin level	1 supporting dataset	Spink12^em1(IMPC)J	homozygote	Early adult	6.61x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spink12.

Associated images

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Histopathology

There is no histopathology data found for Spink12.

IMPC related publications

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External links

No external links available for Spink12.

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*Spink12^em1(IMPC)J*	Intra-exon deletion	‌	mouse
*Spink12^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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