Esco1 | establishment of sister chromatid cohesion N-acetyltransferase 1

GeneMGI:1925055Synonyms: A930014I12Rik

Physiological systems

11 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton

7 No significant impact

13 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body weight	4 supporting datasets	Esco1^{tm1(KOMP)Wtsi}	homozygote	Early adult	4x10^-8
increased bone mineral density	1 supporting dataset	Esco1^{tm1(KOMP)Wtsi}	homozygote	Early adult	2.3x10^-5
increased lean body mass	1 supporting dataset	Esco1^{tm1(KOMP)Wtsi}	homozygote	Early adult	5.53x10^-5
decreased total body fat amount	1 supporting dataset	Esco1^{tm1(KOMP)Wtsi}	homozygote	Early adult	3.8x10^-5
decreased circulating cholesterol level	1 supporting dataset	Esco1^{tm1(KOMP)Wtsi}	homozygote	Early adult	5.06x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Esco1.

Associated images

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Histopathology

There is no histopathology data found for Esco1.

IMPC related publications

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External links

No external links available for Esco1.

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*Esco1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell mouse
*Esco1^{tm455221(L1L2_GT2_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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