Mmab | methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)

GeneMGI:1924947Synonyms: 9130222L19Rik, ATP:Cob(I)alamin Adenosyltransferase

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Mortality/aging Cardiovascular system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Mmab^{em1(IMPC)Hmgu}	homozygote	Early adult	N/A ^*
prolonged RR interval	1 supporting dataset	Mmab^{em1(IMPC)Hmgu}	heterozygote	Early adult	4.58x10^-8
abnormal spleen morphology	1 supporting dataset	Mmab^{em1(IMPC)Hmgu}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmab.

Associated images

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Histopathology

There is no histopathology data found for Mmab.

IMPC related publications

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External links

No external links available for Mmab.

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*Mmab^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Mmab^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mmab^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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