Ric1 | RAB6A GEF complex partner 1

GeneMGI:1924893Synonyms: C130057E09Rik, C030046E11Rik

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased hemoglobin content	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.14x10^-22
increased mean corpuscular volume	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	6.72x10^-7
decreased erythrocyte cell number	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.17x10^-11
abnormal behavior	3 supporting datasets	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3.86x10^-26
increased circulating alanine transaminase level	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.01x10^-11
decreased leukocyte cell number	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.48x10^-5
increased grip strength	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.41x10^-5
decreased B cell number	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.11x10^-14
decreased hematocrit	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	7.59x10^-7
increased heart weight	1 supporting dataset	Ric1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	7.6x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ric1.

Associated images

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Histopathology

There is no histopathology data found for Ric1.

IMPC related publications

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External links

No external links available for Ric1.

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*Ric1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ric1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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