Smpd4 | sphingomyelin phosphodiesterase 4

GeneMGI:1924876Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Reproductive system Mortality/aging

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

1Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Smpd4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
male infertility	1 supporting dataset	Smpd4^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Smpd4.

Associated images

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Histopathology

There is no histopathology data found for Smpd4.

IMPC related publications

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External links

No external links available for Smpd4.

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*Smpd4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Smpd4^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Smpd4^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Smpd4^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Smpd4^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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