Spidr | scaffolding protein involved in DNA repair

GeneMGI:1924834Synonyms: 2310008H04Rik

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Reproductive system Adipose tissue Growth/size/body region Vision/eye Skeleton

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:51Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral density	1 supporting dataset	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.62x10^-9
decreased bone mineral content	2 supporting datasets	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.5x10^-10
increased total body fat amount	2 supporting datasets	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.89x10^-8
female infertility	1 supporting dataset	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal eye posterior chamber depth	1 supporting dataset	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.23x10^-6
decreased lean body mass	2 supporting datasets	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.62x10^-6
male infertility	1 supporting dataset	Spidr^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spidr.

Associated images

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Histopathology

There is no histopathology data found for Spidr.

IMPC related publications

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External links

No external links available for Spidr.

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*Spidr^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Spidr^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Spidr^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Spidr^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Spidr^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Spidr^{tm3a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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