Notum | notum palmitoleoyl-protein carboxylesterase

GeneMGI:1924833Synonyms: 5730593N15Rik

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Nervous system Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal brain morphology	1 supporting dataset	Notum^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Notum^em1(IMPC)Tcp	homozygote	E18.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Early adult	1.49x10^-8
decreased grip strength	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Late adult	4.85x10^-5
preweaning lethality, incomplete penetrance	3 supporting datasets	Notum^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Early adult	7.03x10^-5
small spleen	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
small ovary	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
small uterus	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Notum^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Notum.

Associated images

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Histopathology

There is no histopathology data found for Notum.

IMPC related publications

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External links

No external links available for Notum.

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*Notum^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Notum^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Notum^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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