Vps33a | VPS33A CORVET/HOPS core subunit

GeneMGI:1924823Synonyms: 3830421M04Rik, bf

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Mortality/aging Cardiovascular system Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged kidney	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Vps33a^em2(IMPC)Tcp	homozygote	E9.5	N/A ^*
decreased lymphocyte cell number	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Early adult	3.62x10^-5
increased red blood cell distribution width	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Early adult	1.83x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Vps33a^em2(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Early adult	1.33x10^-6
increased heart weight	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Early adult	1.1x10^-6
enlarged urinary bladder	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal sternum morphology	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
short tibia	1 supporting dataset	Vps33a^em2(IMPC)Tcp	heterozygote	Late adult	2.47x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vps33a.

Associated images

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Histopathology

There is no histopathology data found for Vps33a.

IMPC related publications

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External links

No external links available for Vps33a.

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*Vps33a^em2(IMPC)Tcp*	Exon Deletion	‌	mouse
*Vps33a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Vps33a^{tm210940(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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