Agl | amylo-1,6-glucosidase, 4-alpha-glucanotransferase

GeneMGI:1924809Synonyms: 1110061O17Rik, 9430004C13Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton Cardiovascular system Mortality/aging Renal/urinary system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:21Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased heart weight	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.75x10^-10
cataract	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.7x10^-14
increased circulating cholesterol level	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.1x10^-5
increased kidney weight	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.94x10^-9
increased lean body mass	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.49x10^-9
decreased bone mineral content	2 supporting datasets	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.12x10^-9
increased circulating iron level	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
decreased circulating glucose level	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	0
abnormal gait	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.75x10^-5
tremors	1 supporting dataset	Agl^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.97x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Agl.

Associated images

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Histopathology

There is no histopathology data found for Agl.

IMPC related publications

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External links

No external links available for Agl.

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*Agl^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Agl^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Agl^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Agl^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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