Tmem116 | transmembrane protein 116

GeneMGI:1924712Synonyms: 4930406A18Rik, 4930513P12Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal lens morphology	2 supporting datasets	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.21x10^-9
enlarged lymph nodes	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
abnormal lung morphology	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased body weight	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Middle aged adult	5.78x10^-5
improved glucose tolerance	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.1x10^-6
enlarged spleen	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased circulating alkaline phosphatase level	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.74x10^-5
increased grip strength	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.11x10^-5
abnormal startle reflex	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	1.58x10^-6
decreased circulating total protein level	1 supporting dataset	Tmem116^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.85x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem116.

Associated images

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Histopathology

There is no histopathology data found for Tmem116.

IMPC related publications

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External links

No external links available for Tmem116.

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*Tmem116^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Tmem116^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tmem116^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tmem116^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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