Sorbs2 | sorbin and SH3 domain containing 2

GeneMGI:1924574Synonyms: 9430041O17Rik, 2010203O03Rik

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased circulating free fatty acids level	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	3.23x10^-6
increased circulating sodium level	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	3.43x10^-6
decreased circulating glucose level	2 supporting datasets	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	2.16x10^-7
decreased exploration in new environment	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	2.97x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	8.89x10^-6
shortened PR interval	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	1.97x10^-6
increased heart rate	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	2.85x10^-5
decreased circulating cholesterol level	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	3.24x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	1.64x10^-6
abnormal retina morphology	1 supporting dataset	Sorbs2^{tm1.1(KOMP)Mbp}	homozygote	Early adult	2.61x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sorbs2.

Associated images

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Histopathology

There is no histopathology data found for Sorbs2.

IMPC related publications

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External links

No external links available for Sorbs2.

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*Sorbs2^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Sorbs2^{tm1.1(KOMP)Mbp}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Sorbs2^{tm443565(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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