Pbrm1 | polybromo 1

GeneMGI:1923998Synonyms: Pb1, 2610016F04Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal kidney morphology	1 supporting dataset	Pbrm1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Pbrm1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.26x10^-7
decreased circulating creatinine level	1 supporting dataset	Pbrm1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.71x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Pbrm1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	1 supporting dataset	Pbrm1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.24x10^-5
abnormal gait	1 supporting dataset	Pbrm1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.05x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pbrm1.

Associated images

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Histopathology

There is no histopathology data found for Pbrm1.

IMPC related publications

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External links

No external links available for Pbrm1.

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*Pbrm1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pbrm1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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