Arpc2 | actin related protein 2/3 complex, subunit 2

GeneMGI:1923959Synonyms: p34-Arc, 2210023N03Rik

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Pigmentation Integument Growth/size/body region Hematopoietic system Skeleton Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body weight	4 supporting datasets	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.87x10^-9
preweaning lethality, complete penetrance	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.64x10^-6
increased leukocyte cell number	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.49x10^-5
increased mean corpuscular volume	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.89x10^-5
vertebral fusion	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.22x10^-5
increased mean corpuscular hemoglobin	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.97x10^-5
increased body length	1 supporting dataset	Arpc2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.61x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arpc2.

Associated images

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Histopathology

There is no histopathology data found for Arpc2.

IMPC related publications

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External links

No external links available for Arpc2.

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*Arpc2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Arpc2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Arpc2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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