Mmaa | methylmalonic aciduria (cobalamin deficiency) type A

GeneMGI:1923805Synonyms: 2810018E08Rik

Physiological systems

17 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Integument Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

7 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:32Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased thigmotaxis	2 supporting datasets	Mmaa^em1(IMPC)J	homozygote	Early adult	6.4x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Early adult	3.68x10^-6
decreased locomotor activity	8 supporting datasets	Mmaa^em1(IMPC)J	homozygote	Early adult	2.89x10^-14
increased circulating alkaline phosphatase level	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Early adult	0
decreased locomotor activity	8 supporting datasets	Mmaa^em1(IMPC)J	homozygote	Late adult	1.15x10^-9
thrombocytopenia	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Early adult	1.37x10^-11
decreased bone mineral density	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Late adult	1.61x10^-9
increased mean corpuscular hemoglobin	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Early adult	9.5x10^-15
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Early adult	2.91x10^-5
female infertility	1 supporting dataset	Mmaa^em1(IMPC)J	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmaa.

Associated images

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Histopathology

There is no histopathology data found for Mmaa.

IMPC related publications

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External links

No external links available for Mmaa.

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*Mmaa^em1(IMPC)J*	Exon Deletion	‌	mouse
*Mmaa^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell

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