Lsm8 | LSM8 homolog, U6 small nuclear RNA associated

GeneMGI:1923772Synonyms: 2010003I05Rik, Lsm8

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Mortality/aging

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating serum albumin level	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	1.65x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	6.92x10^-39
enlarged lymph nodes	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Lsm8^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Lsm8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased blood urea nitrogen level	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	3.18x10^-6
small seminal vesicle	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
increased circulating creatinine level	1 supporting dataset	Lsm8^em1(IMPC)Mbp	heterozygote	Early adult	2.64x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lsm8.

Associated images

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Histopathology

There is no histopathology data found for Lsm8.

IMPC related publications

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External links

No external links available for Lsm8.

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*Lsm8^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Lsm8^{tm42755(L1L2_6XOspnEnh_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Lsm8^{tm42755(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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