Uhrf2 | ubiquitin-like, containing PHD and RING finger domains 2

GeneMGI:1923718Synonyms: 2310065A22Rik, D130071B19Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system

9 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

60Embryo tissues

Phenotypes

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.92x10^-5
preweaning lethality, incomplete penetrance	3 supporting datasets	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased heart rate	1 supporting dataset	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.84x10^-6
increased leukocyte cell number	1 supporting dataset	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.39x10^-5
decreased lean body mass	2 supporting datasets	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.03x10^-6
decreased bone mineral content	2 supporting datasets	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.48x10^-9
abnormal bone structure	1 supporting dataset	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.07x10^-8
increased total body fat amount	2 supporting datasets	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.85x10^-9
prolonged RR interval	1 supporting dataset	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.13x10^-7
hyperactivity	2 supporting datasets	Uhrf2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.96x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Uhrf2.

Associated images

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Histopathology

There is no histopathology data found for Uhrf2.

IMPC related publications

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External links

No external links available for Uhrf2.

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*Uhrf2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Uhrf2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Uhrf2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Uhrf2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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