Knl1 | kinetochore scaffold 1

GeneMGI:1923714Synonyms: 2310043D08Rik, Casc5, +1 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging Cardiovascular system

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Knl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
cardiovascular system phenotype	1 supporting dataset	Knl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.69x10^-5
impaired glucose tolerance	1 supporting dataset	Knl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.49x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Knl1.

Associated images

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Histopathology

There is no histopathology data found for Knl1.

IMPC related publications

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External links

No external links available for Knl1.

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*Knl1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Knl1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Knl1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes