Daam2 | dishevelled associated activator of morphogenesis 2

GeneMGI:1923691Synonyms: 2310016D11Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Skeleton Craniofacial

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Allele:

Phy. System:



increased circulating amylase level	1 supporting dataset	Daam2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.91x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Daam2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.4x10^-6
increased circulating phosphate level	1 supporting dataset	Daam2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.87x10^-7
abnormal maxilla morphology	1 supporting dataset	Daam2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.28x10^-5
abnormal snout morphology	2 supporting datasets	Daam2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.7x10^-10
increased fasting circulating glucose level	1 supporting dataset	Daam2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.2x10^-5
abnormal snout morphology	1 supporting dataset	Daam2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.5x10^-10
increased hemoglobin content	1 supporting dataset	Daam2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.7x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Daam2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.45x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Daam2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.85x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Daam2.

Associated images

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Histopathology

There is no histopathology data found for Daam2.

IMPC related publications

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External links

No external links available for Daam2.

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*Daam2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Daam2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Daam2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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