Gene: Pcnp MGI:1923552
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal forebrain development | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
prenatal lethality prior to heart atrial septation | Pcnpem1(IMPC)Mbp | HOM | E15.5 | 0.00 | ||
abnormal heart morphology | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal neural tube closure | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal skin morphology | Pcnpem1(IMPC)Mbp | HET | Early adult | 0.00 | ||
abnormal midbrain development | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal pharyngeal arch morphology | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal neural tube morphology | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
enlarged epididymis | Pcnpem1(IMPC)Mbp | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Pcnpem1(IMPC)Mbp | HOM | Early adult | 0.00 | ||
abnormal embryo turning | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal optic vesicle formation | Pcnpem1(IMPC)Mbp | HOM | E9.5 | 0.00 | ||
abnormal neural tube morphology | Pcnpem1(IMPC)Mbp | HET | E9.5 | 0.00 | ||
abnormal epididymis morphology | Pcnpem1(IMPC)Mbp | HET | Early adult | 0.00 |
Human diseases caused by Pcnp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Pcnp by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Pcnp
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MGI Allele | Allele Type | Produced |
---|---|---|
Pcnpem1(IMPC)Mbp | Exon Deletion | Mice, Tissue |
Pcnptm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
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