Kti12 | KTI12 homolog, chromatin associated

GeneMGI:1923547Synonyms: 1110001A12Rik

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Adipose tissue Growth/size/body region Skeleton Mortality/aging

14 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetKti12tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetKti12tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
increased total body fat amount2 supporting datasetsKti12tm1.1(KOMP)VlcgheterozygoteEarly adult7.03x10-7 
decreased lean body mass1 supporting datasetKti12tm1.1(KOMP)VlcgheterozygoteEarly adult1.27x10-5 
decreased bone mineral density1 supporting datasetKti12tm1.1(KOMP)VlcgheterozygoteEarly adult3.97x10-6 
decreased bone mineral content2 supporting datasetsKti12tm1.1(KOMP)VlcgheterozygoteEarly adult2.1x10-9 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Kti12tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Kti12tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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