Cyrib | CYFIP related Rac1 interactor B

GeneMGI:1923520Synonyms: Fam49b, 0910001A06Rik

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Vision/eye Behavior/neurological Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
60Embryo tissues

Phenotypes

edema1 supporting datasetCyribtm1b(KOMP)WtsihomozygoteE15.5N/A * 
abnormal retina morphology1 supporting datasetCyribtm1b(KOMP)WtsiheterozygoteEarly adult1.4x10-10 
decreased exploration in new environment1 supporting datasetCyribtm1b(KOMP)WtsiheterozygoteEarly adult3.01x10-5 
male infertility1 supporting datasetCyribtm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal retina morphology1 supporting datasetCyribtm1b(KOMP)WtsihomozygoteEarly adult1.98x10-5 
preweaning lethality, incomplete penetrance3 supporting datasetsCyribtm1b(KOMP)WtsihomozygoteEarly adultN/A * 
decreased circulating sodium level1 supporting datasetCyribtm1b(KOMP)WtsiheterozygoteEarly adult1.49x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cyribtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cyribtm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Cyribtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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