Fads1 | fatty acid desaturase 1

GeneMGI:1923517Synonyms: 0710001O03Rik, A930006B21Rik

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Nervous system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased kidney weight	2 supporting datasets	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.97x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.02x10^-11
decreased circulating cholesterol level	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.52x10^-7
small testis	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased brain weight	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.67x10^-8
improved glucose tolerance	2 supporting datasets	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.98x10^-5
decreased locomotor activity	3 supporting datasets	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.17x10^-6
decreased circulating triglyceride level	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.81x10^-5
decreased exploration in new environment	1 supporting dataset	Fads1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.22x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fads1.

Associated images

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Histopathology

There is no histopathology data found for Fads1.

IMPC related publications

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External links

No external links available for Fads1.

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*Fads1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Fads1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Fads1^{tm108600(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Fads1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Fads1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Fads1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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