Cant1 | calcium activated nucleotidase 1

GeneMGI:1923275Synonyms: D11Bwg0554e, Apy1h, +3 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal retina morphology	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.85x10^-7
decreased total retina thickness	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.79x10^-5
increased circulating amylase level	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.71x10^-7
abnormal lens morphology	3 supporting datasets	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.35x10^-9
preweaning lethality, incomplete penetrance	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.62x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.97x10^-5
increased circulating lipase level	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.09x10^-8
abnormal retina vasculature morphology	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.69x10^-10
abnormal tail morphology	1 supporting dataset	Cant1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.7x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cant1.

Associated images

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Histopathology

There is no histopathology data found for Cant1.

IMPC related publications

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External links

No external links available for Cant1.

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*Cant1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cant1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cant1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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