Sesn3 | sestrin 3

GeneMGI:1922997Synonyms: SEST3, 5630400E15Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	1 supporting dataset	Sesn3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.86x10^-5
decreased mean corpuscular volume	1 supporting dataset	Sesn3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.6x10^-6
increased circulating chloride level	1 supporting dataset	Sesn3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.52x10^-5
decreased total body fat amount	1 supporting dataset	Sesn3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.2x10^-5
decreased circulating LDL cholesterol level	1 supporting dataset	Sesn3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.16x10^-5
increased circulating sodium level	1 supporting dataset	Sesn3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.63x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sesn3.

Associated images

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Histopathology

There is no histopathology data found for Sesn3.

IMPC related publications

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External links

No external links available for Sesn3.

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*Sesn3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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