Prpf6 | pre-mRNA splicing factor 6

GeneMGI:1922946Synonyms: ANT-1, 1190003A07Rik, +2 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:49Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:



hyperactivity	5 supporting datasets	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.54x10^-6
decreased circulating calcium level	1 supporting dataset	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.13x10^-5
decreased thigmotaxis	2 supporting datasets	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.89x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Prpf6^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
impaired righting response	1 supporting dataset	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	8.23x10^-12
increased mean corpuscular hemoglobin	1 supporting dataset	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.71x10^-9
decreased circulating glucose level	1 supporting dataset	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.15x10^-5
abnormal behavior	1 supporting dataset	Prpf6^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.9x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prpf6.

Associated images

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Histopathology

There is no histopathology data found for Prpf6.

IMPC related publications

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External links

No external links available for Prpf6.

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*Prpf6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Prpf6^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Prpf6^{tm354908(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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