Bicdl1 | BICD family like cargo adaptor 1

GeneMGI:1922915Synonyms: Ccdc64, BICDR-1, +1 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	2 supporting datasets	Bicdl1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	heterozygote	E18.5	N/A ^*
short tibia	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	1.74x10^-6
enlarged spleen	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased heart rate variability	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	9.31x10^-5
decreased vertical activity	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	6.54x10^-5
cardiovascular system phenotype	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	2.61x10^-5
abnormal spleen morphology	1 supporting dataset	Bicdl1^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bicdl1.

Associated images

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Histopathology

There is no histopathology data found for Bicdl1.

IMPC related publications

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External links

No external links available for Bicdl1.

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*Bicdl1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Bicdl1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Bicdl1^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bicdl1^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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