Ing5 | inhibitor of growth family, member 5

GeneMGI:1922816Synonyms: 1810018M11Rik, 1700027H23Rik

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Vision/eye Cardiovascular system Mortality/aging Craniofacial

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

sclerocornea1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult6.91x10-5 
cornea vascularization1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult1.53x10-5 
increased fasting circulating glucose level1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult1.7x10-6 
impaired glucose tolerance1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult1.14x10-8 
preweaning lethality, incomplete penetrance1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adultN/A * 
prolonged QRS complex duration1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult8.89x10-7 
abnormal snout morphology1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult5.63x10-7 
increased circulating cholesterol level1 supporting datasetIng5em1(IMPC)JhomozygoteEarly adult1.11x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ing5em1(IMPC)JExon Deletionmouse
Ing5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Ing5tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ing5tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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