Dynlrb2 | dynein light chain roadblock-type 2

GeneMGI:1922715Synonyms: 1700009A04Rik, Dncl2b, +1 more

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Hematopoietic system Cardiovascular system Mortality/aging

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased mean platelet volume	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	3.71x10^-5
increased heart weight	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.18x10^-8
increased circulating phosphate level	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	4.75x10^-5
decreased total body fat amount	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.47x10^-7
increased fasting circulating glucose level	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.14x10^-6
male infertility	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	8.79x10^-8
increased circulating magnesium level	1 supporting dataset	Dynlrb2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	5.35x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dynlrb2.

Associated images

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Histopathology

There is no histopathology data found for Dynlrb2.

IMPC related publications

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External links

No external links available for Dynlrb2.

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*Dynlrb2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse

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