Mettl5 | methyltransferase 5, N6-adenosine

GeneMGI:1922672Synonyms: 2810410A08Rik

Physiological systems

20 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hearing/vestibular/ear Vision/eye Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging Craniofacial

8 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:28Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased body length	1 supporting dataset	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	9.82x10^-7
decreased thigmotaxis	2 supporting datasets	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	6.54x10^-8
increased grip strength	1 supporting dataset	Mettl5^{em1(IMPC)Hmgu}	heterozygote	Early adult	2.12x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	4.68x10^-8
abnormal auditory brainstem response	3 supporting datasets	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	2.81x10^-9
increased hematocrit	1 supporting dataset	Mettl5^{em1(IMPC)Hmgu}	heterozygote	Early adult	2.51x10^-5
abnormal vitreous body morphology	1 supporting dataset	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	6.28x10^-13
decreased locomotor activity	3 supporting datasets	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	7.31x10^-9
decreased anxiety-related response	1 supporting dataset	Mettl5^{em1(IMPC)Hmgu}	homozygote	Early adult	3.45x10^-9
abnormal auditory brainstem response	3 supporting datasets	Mettl5^{em1(IMPC)Hmgu}	heterozygote	Early adult	1.26x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mettl5.

Associated images

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Histopathology

There is no histopathology data found for Mettl5.

IMPC related publications

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External links

No external links available for Mettl5.

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*Mettl5^{em1(IMPC)Hmgu}*	Indel	‌	mouse
*Mettl5^{tm50967(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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