Sirt4 | sirtuin 4

GeneMGI:1922637Synonyms: 4930596O17Rik

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Sirt4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.63x10^-13
abnormal gait	1 supporting dataset	Sirt4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.49x10^-7
increased circulating serum albumin level	1 supporting dataset	Sirt4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.59x10^-5
increased circulating total protein level	1 supporting dataset	Sirt4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.71x10^-7
increased circulating fructosamine level	1 supporting dataset	Sirt4^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.61x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sirt4.

Associated images

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Histopathology

There is no histopathology data found for Sirt4.

IMPC related publications

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External links

No external links available for Sirt4.

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*Sirt4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sirt4^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sirt4^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Sirt4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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