Asxl2 | ASXL transcriptional regulator 2
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Hematopoietic system Mortality/aging Cardiovascular system
12 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.92x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.14x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.24x10-6 | ||
| prolonged QRS complex duration | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.48x10-5 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.85x10-6 | ||
| increased circulating cholesterol level | 1 supporting dataset | Asxl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.49x10-5 |
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External links
No external links available for Asxl2.
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| Asxl2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Asxl2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Asxl2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |