Mei4 | meiotic double-stranded break formation protein 4

GeneMGI:1922283Synonyms: 4930486G11Rik

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Vision/eye Renal/urinary system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	4.35x10^-5
abnormal testis morphology	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	1.38x10^-7
increased circulating aspartate transaminase level	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	2.65x10^-6
cataract	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	9.23x10^-5
abnormal vitreous body morphology	1 supporting dataset	Mei4^em1(IMPC)Mbp	homozygote	Early adult	7.3x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mei4.

Associated images

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Histopathology

There is no histopathology data found for Mei4.

IMPC related publications

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External links

No external links available for Mei4.

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*Mei4^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Mei4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mei4^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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