Pik3cb | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

GeneMGI:1922019Synonyms: 1110001J02Rik, p110beta

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Hematopoietic system

15 No significant impact

5 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation1 supporting datasetPik3cbtm1a(EUCOMM)WtsihomozygoteEarly adult2.17x10-5 
increased hemoglobin content1 supporting datasetPik3cbtm1a(EUCOMM)WtsihomozygoteEarly adult5x10-5 
increased mean corpuscular hemoglobin1 supporting datasetPik3cbtm1a(EUCOMM)WtsiheterozygoteEarly adult6.31x10-5 
decreased circulating creatinine level1 supporting datasetPik3cbtm1a(EUCOMM)WtsiheterozygoteEarly adult3.43x10-6 
increased hemoglobin content1 supporting datasetPik3cbtm1a(EUCOMM)WtsiheterozygoteEarly adult1.97x10-5 
increased mean corpuscular hemoglobin1 supporting datasetPik3cbtm1a(EUCOMM)WtsihomozygoteEarly adult4.28x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pik3cbtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Pik3cbtm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Pik3cbtm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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