Pank2 | pantothenate kinase 2

GeneMGI:1921700Synonyms: 4933409I19Rik

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



small testis	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased freezing behavior	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.81x10^-6
immune system phenotype	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.4x10^-5
enlarged heart	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
male infertility	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased effector memory CD8-positive, alpha-beta T cell number	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.29x10^-5
abnormal spleen morphology	2 supporting datasets	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal digit morphology	1 supporting dataset	Pank2^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.99x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pank2.

Associated images

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Histopathology

There is no histopathology data found for Pank2.

IMPC related publications

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External links

No external links available for Pank2.

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*Pank2^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Pank2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Pank2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pank2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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