Dpp8 | dipeptidylpeptidase 8

GeneMGI:1921638Synonyms: 2310004I03Rik, 4932434F09Rik

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	2.17x10^-5
decreased locomotor activity	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	5.64x10^-5
decreased circulating calcium level	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	2.26x10^-11
decreased bone mineral content	2 supporting datasets	Dpp8^em1(IMPC)J	homozygote	Early adult	1.38x10^-24
decreased heart weight	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	2.09x10^-5
abnormal bone structure	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	3.54x10^-15
prolonged RR interval	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	1.75x10^-8
decreased vertical activity	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	3.12x10^-6
increased mean corpuscular volume	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	3.46x10^-7
decreased lean body mass	1 supporting dataset	Dpp8^em1(IMPC)J	homozygote	Early adult	9.08x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dpp8.

Associated images

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Histopathology

There is no histopathology data found for Dpp8.

IMPC related publications

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External links

No external links available for Dpp8.

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*Dpp8^em1(IMPC)J*	Exon Deletion	‌	mouse
*Dpp8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dpp8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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