Mettl23 | methyltransferase like 23

GeneMGI:1921569Synonyms: 1500035B17Rik, 1110005A03Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased spleen weight	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	2.92x10^-6
abnormal retina morphology	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	5.12x10^-18
increased mean platelet volume	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	5.63x10^-11
decreased locomotor activity	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	2.45x10^-5
abnormal behavior	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	1.12x10^-6
decreased thigmotaxis	2 supporting datasets	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	1.7x10^-9
increased total retina thickness	2 supporting datasets	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	2.04x10^-6
abnormal head size	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	3.28x10^-10
decreased startle reflex	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	1.39x10^-5
abnormal head morphology	1 supporting dataset	Mettl23^{em1(IMPC)Hmgu}	homozygote	Early adult	2.37x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mettl23.

Associated images

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Histopathology

There is no histopathology data found for Mettl23.

IMPC related publications

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External links

No external links available for Mettl23.

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*Mettl23^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Mettl23^{em1(IMPC)Rbrc}*	Inter-exon deletion	‌	mouse
*Mettl23^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Mettl23^{tm213121(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector
*Mettl23^{tm456238(L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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