Chic2 | cysteine-rich hydrophobic domain 2

GeneMGI:1921527Synonyms: 4930502K01Rik, 1700081B18Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Pigmentation Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

10 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal coat/hair pigmentation	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.54x10^-8
enlarged spleen	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased circulating amylase level	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.85x10^-10
enlarged ovary	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.59x10^-5
iris synechia	1 supporting dataset	Chic2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.61x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chic2.

Associated images

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Histopathology

There is no histopathology data found for Chic2.

IMPC related publications

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External links

No external links available for Chic2.

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*Chic2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Chic2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Chic2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Chic2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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