Cldnd2 | claudin domain containing 2

GeneMGI:1921526Synonyms: 1700071E18Rik

Physiological systems

16 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye

14 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased fasting circulating glucose level1 supporting datasetCldnd2tm1b(EUCOMM)HmguhomozygoteEarly adult3.99x10-5 
increased circulating calcium level1 supporting datasetCldnd2tm1b(EUCOMM)HmguhomozygoteEarly adult1.82x10-5 
increased cornea thickness1 supporting datasetCldnd2tm1b(EUCOMM)HmguhomozygoteEarly adult6.9x10-5 
increased circulating total protein level1 supporting datasetCldnd2tm1b(EUCOMM)HmguhomozygoteEarly adult2.07x10-5 
increased circulating serum albumin level1 supporting datasetCldnd2tm1b(EUCOMM)HmguhomozygoteEarly adult1.01x10-5 
abnormal cholesterol homeostasis1 supporting datasetCldnd2tm1b(EUCOMM)HmguhomozygoteEarly adult4.26x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cldnd2tm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Cldnd2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cldnd2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Cldnd2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Cldnd2tm210897(L1L2_Pgk_P)Reporter-tagged deletion allele (with selection cassette)targeting vector

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