Atg7 | autophagy related 7

GeneMGI:1921494Synonyms: 1810013K23Rik, Apg7l

Physiological systems

23 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Endocrine/exocrine gland Embryo Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	7.39x10^-6
abnormal heart morphology	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased circulating serum albumin level	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	8.06x10^-5
abnormal mammary gland morphology	2 supporting datasets	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	homozygote	E18.5	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.18x10^-7
abnormal embryo size	1 supporting dataset	Atg7^{em1(IMPC)Ccpcz}	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atg7.

Associated images

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Histopathology

There is no histopathology data found for Atg7.

IMPC related publications

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External links

No external links available for Atg7.

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*Atg7^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Atg7^{tm172409(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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