Dnal1 | dynein, axonemal, light chain 1

GeneMGI:1921462Synonyms: Dnal1, Dnalc1, +2 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Digestive/alimentary Respiratory system Hematopoietic system Mortality/aging Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased eosinophil cell number	2 supporting datasets	Dnal1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.29x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Dnal1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal lung morphology	1 supporting dataset	Dnal1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
edema	1 supporting dataset	Dnal1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
polycystic kidney	1 supporting dataset	Dnal1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal ileum morphology	1 supporting dataset	Dnal1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
increased respiratory quotient	1 supporting dataset	Dnal1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.42x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnal1.

Associated images

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Histopathology

There is no histopathology data found for Dnal1.

IMPC related publications

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External links

No external links available for Dnal1.

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*Dnal1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Dnal1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Dnal1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dnal1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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