Opa1 | OPA1, mitochondrial dynamin like GTPase
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Craniofacial Mortality/aging Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:13Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal heart morphology | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal neural tube closure | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Opa1em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal somite shape | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Opa1em1(IMPC)Bay | heterozygote | Early adult | 7.86x10-5 | ||
| abnormal visceral yolk sac morphology | 1 supporting dataset | Opa1em1(IMPC)Bay | homozygote | E9.5 | N/A * |
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External links
No external links available for Opa1.
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| Opa1em1(IMPC)Bay | Exon Deletion | | mouse |
| Opa1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Opa1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |