Syce1 | synaptonemal complex central element protein 1

GeneMGI:1921325Synonyms: 4933406J07Rik

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Vision/eye Behavior/neurological Skeleton Renal/urinary system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal lens morphology	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.39x10^-6
increased thigmotaxis	2 supporting datasets	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Late adult	5.36x10^-5
limb grasping	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.51x10^-5
decreased grip strength	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Late adult	9.79x10^-6
improved glucose tolerance	2 supporting datasets	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.18x10^-5
male infertility	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased urine microalbumin level	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.44x10^-5
decreased locomotor activity	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Late adult	2.94x10^-7
decreased bone mineral density	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.35x10^-5
increased fasting circulating glucose level	1 supporting dataset	Syce1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.11x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Syce1.

Associated images

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Histopathology

There is no histopathology data found for Syce1.

IMPC related publications

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External links

No external links available for Syce1.

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*Syce1^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Syce1^{tm119206(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Syce1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Syce1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Syce1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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