Arhgef6 | Rac/Cdc42 guanine nucleotide exchange factor 6

GeneMGI:1920591Synonyms: 1600028C08Rik, 1700038J06Rik, +2 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



enlarged lymph nodes	1 supporting dataset	Arhgef6^{tm2e.1(EUCOMM)Wtsi}	hemizygote	Early adult	N/A ^*
increased circulating potassium level	1 supporting dataset	Arhgef6^{tm2e.1(EUCOMM)Wtsi}	homozygote	Early adult	3.9x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Arhgef6^{tm2e.1(EUCOMM)Wtsi}	homozygote	Early adult	3.39x10^-8
decreased lymphocyte cell number	1 supporting dataset	Arhgef6^{tm2e.1(EUCOMM)Wtsi}	homozygote	Early adult	9.56x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef6.

Associated images

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Histopathology

There is no histopathology data found for Arhgef6.

IMPC related publications

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External links

No external links available for Arhgef6.

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*Arhgef6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Arhgef6^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Arhgef6^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Arhgef6^{tm2e.1(EUCOMM)Wtsi}*	Promoter excision from Targeted, non-conditional allele	‌	mouse
*Arhgef6^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Arhgef6^{tm40717(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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