C9orf72 | C9orf72, member of C9orf72-SMCR8 complex

GeneMGI:1920455Synonyms: Dennd9, 3110043O21Rik

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Hematopoietic system Skeleton

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

7Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	2 supporting datasets	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	6.03x10^-17
decreased total body fat amount	2 supporting datasets	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	2.39x10^-7
increased spleen weight	1 supporting dataset	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	1.43x10^-119
increased lean body mass	1 supporting dataset	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	4.06x10^-6
small testis	1 supporting dataset	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	N/A ^*
abnormal vertebral arch morphology	1 supporting dataset	C9orf72^{tm1.1(KOMP)Mbp}	homozygote	Early adult	2.67x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for C9orf72.

Associated images

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Histopathology

There is no histopathology data found for C9orf72.

IMPC related publications

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External links

No external links available for C9orf72.

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*C9orf72^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*C9orf72^{tm1.1(KOMP)Mbp}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*C9orf72^{tm406904(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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