Tppp | tubulin polymerization promoting protein

GeneMGI:1920198Synonyms: 2900041A09Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Hematopoietic system Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased thigmotaxis	4 supporting datasets	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.58x10^-9
increased erythrocyte cell number	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.31x10^-9
increased circulating chloride level	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.19x10^-6
hyperactivity	8 supporting datasets	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.91x10^-20
increased circulating alkaline phosphatase level	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.11x10^-6
abnormal behavior	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.58x10^-9
increased hemoglobin content	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.68x10^-9
increased exploration in new environment	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.26x10^-5
abnormal sleep behavior	2 supporting datasets	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.03x10^-7
increased hematocrit	1 supporting dataset	Tppp^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.87x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tppp.

Associated images

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Histopathology

There is no histopathology data found for Tppp.

IMPC related publications

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External links

No external links available for Tppp.

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*Tppp^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Tppp^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Tppp^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tppp^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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