Tonsl | tonsoku-like, DNA repair protein
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Mortality/aging Cardiovascular system
16 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Tonslem1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| increased heart left ventricle size | 1 supporting dataset | Tonslem1(IMPC)Bay | heterozygote | Early adult | 3.64x10-6 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Tonslem2(IMPC)Bay | homozygote | Early adult | N/A * | ||
| thick ventricular wall | 1 supporting dataset | Tonslem1(IMPC)Bay | heterozygote | Early adult | 3.86x10-5 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Tonslem1(IMPC)Bay | heterozygote | Early adult | 8.88x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Tonslem1(IMPC)Bay | homozygote | E9.5 | N/A * |
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External links
No external links available for Tonsl.
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| Tonslem1(IMPC)Bay | Exon Deletion | | mouse |
| Tonslem2(IMPC)Bay | Point Mutation | | mouse |
| Tonsltm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tonsltm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tonsltm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |