Dis3 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

GeneMGI:1919912Synonyms: 2810028N01Rik

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal retina morphology	1 supporting dataset	Dis3^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	5.86x10^-7
abnormal vitreous body morphology	1 supporting dataset	Dis3^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	6.32x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Dis3^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	9.81x10^-5
impaired glucose tolerance	1 supporting dataset	Dis3^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	3.08x10^-5
increased startle reflex	1 supporting dataset	Dis3^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	3.32x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Dis3^{tm1e.1(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dis3.

Associated images

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Histopathology

There is no histopathology data found for Dis3.

IMPC related publications

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External links

No external links available for Dis3.

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*Dis3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dis3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Dis3^{tm1e.1(EUCOMM)Hmgu}*	Promoter excision from Targeted, non-conditional allele	‌	mouse

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